Download e-book for iPad: Acute Kidney Injury - Scientific Evidence Driving Change in by Rinaldo Bellomo, Joseph Bonventre

By Rinaldo Bellomo, Joseph Bonventre

ISBN-10: 3805586469

ISBN-13: 9783805586467

The sector of acute-care nephrology has lately obvious major adjustments, affecting the definition and category of acute kidney disorder in addition to our knowing of its epidemiology, the power to make previous diagnoses, using novel imaging modalities, and the perception into why acute kidney harm may possibly happen lower than assorted scientific situations. diverse specialists have contributed to this factor, emphasizing the significance of the switch of thought from that of acute renal failure to that of acute kidney injury.This switch has ended in the advance of recent definitions and classifications which, including the knowledge that even minor sub medical damage to the kidney might subject, emphasize the necessity to enhance early biomarkers. Sufficiently early analysis, a greater type method and a clearer knowing of the pathogenesis promise to carry novel and potent cures for sufferers. Summarizing fresh advancements, this book can be an imperative aid for the clinician to figure out the easiest treatment plans for his sufferers.

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Extra resources for Acute Kidney Injury - Scientific Evidence Driving Change in Patient Management (Nephron Vol. 109, No. 4)

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USA Key Words Acute kidney injury ؒ Iodinated contrast ؒ Chronic kidney disease ؒ Cardiovascular disease ؒ Porphylaxis ؒ Osmolality Abstract Many radiographic studies and procedures use iodinated contrast media and consequently pose the risk of contrastinduced acute kidney injury (AKI). This is an important complication, which accounts for a significant number of cases of hospital-acquired renal failure associated increased hospital length of stay and increased mortality. Sustained reductions in renal blood flow, hypoxic injury, direct cellular toxicity by the contrast media, and superimposed organ injury are all believed to play a role in this form of AKI.

This is also a reflection of our use of models that focus on individual pathophysiological mechanisms, such as ischemia-reperfusion, rather than on models which faithfully reproduce the clinical situation. These two problems have now been addressed – the AKIN criteria addressing the diagnostic heterogeneity issue, and the use of animal models of CSA-AKI by our group and others addressing the second – such that the future is bright for novel preventive agents of CSA-AKI. For an in-depth review of the literature relating to prevention of CSAAKI, readers are referred to the recent paper by Schetz et al.

Copyright © 2008 S. Karger AG, Basel Introduction Severe acute kidney injury requiring acute renal replacement therapy affects approximately 5% of all ICU patients [1]. When recently published consensus criteria (RIFLE criteria) are used to define AKI [2], this condition can be shown to occur in almost 8% of hospital patients [3] and in 150% of ICU patients [4]. Thus, AKI is a major clinical problem in modern hospitals and ICUs. In addition, there is strong evidence that sepsis and septic shock are the most important cause of AKI in critically ill patients and account for 50% or more of cases of AKI in ICU [1, 5].

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Acute Kidney Injury - Scientific Evidence Driving Change in Patient Management (Nephron Vol. 109, No. 4) by Rinaldo Bellomo, Joseph Bonventre


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