By George F. Vande Woude; George Klein (Eds.)
Advances in melanoma examine presents necessary info at the intriguing and fast-moving box of melanoma research. In this half A volume, outstanding and unique experiences offer an outline and synthesis of the most recent options and findings in relation to Clusterin. Chapters contain the shifiting stability among CLU types in the course of tumor development, uclear CLU and the destiny of the phone, and Oxidative pressure in malignant development.
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Extra info for Advances in Cancer Research
105. In any case, this novel knowledge is critical and may have important clinical relevance, considering that strategies for the silencing of CLU gene translation through the use of antisense oligonucleotides (antisense therapy) have been already attempted to enhance apoptosis in oncologic patients. These approaches were based on the knowledge, and reference nucleotide sequences, which are now clearly obsolete. Alternative novel approaches based on upregulation of nCLU in target cells can now be hypothesized and exploited.
Et al. (2003). ASAP: The Alternative Splicing Annotation Project. Nucleic Acids Res. 31, 101–105. Leskov, K. , et al. (2003). Synthesis and functional analyses of nuclear clusterin, a cell death protein. J. Biol. Chem. 278, 11590–11600. , et al. (2006). Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. Oncogene 25, 4890–4903. May, P. , and Finch, C. E. (1992). Sulfated glycoprotein 2: New relationships of this multifunctional protein to neurodegeneration. Trends Neurosci.
1997). It was demonstrated that CPT I interacts with Bcl-2 protein, that regulates programmed cell death in several systems and it is also expressed at the outer mitochondrial membrane (Reed, 1994). 30 Sabina Pucci and Saverio Bettuzzi Bcl-2 binding to CPT I may modulate sphingolipid metabolism in a yet to be defined way and it would control a cell death-specific activity of CPT I at the mitochondrial membrane. In addition, the carnitine system (which comprises carnitine, CPT I, carnitine acetyl transferase, and carnitine translocase) plays an important role in the cell-trafficking of short-chain fatty acids such as acetyl-CoA and works to maintain the acetyl-CoA/CoA ratio (Bremer, 1997).
Advances in Cancer Research by George F. Vande Woude; George Klein (Eds.)