By Frederick W. Alt
Advances in Immunology, a usual and hugely revered ebook, provides present advancements in addition to accomplished stories in immunology. Articles deal with the wide variety of subject matters that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored by way of the major scientists within the box, every one quantity presents updated details and instructions for destiny * Contributions from top experts and specialists * Informs and updates on the entire most up-to-date advancements within the box
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Additional resources for Advances in Immunology, Vol. 102
In most instances, live infection is necessary to prevent CD1a, b, and c expression. , 2006). Besides blocking induction of CD1 expression, some pathogens also appear to selectively downregulate CD1 molecules that are already expressed on DC. , 2004). , 2006). , 1998a,b), live infection with M. tuberculosis downregulated surface CD1 expression in DC. , 1997) and expression was actually upregulated strongly in another 34 Nadia R. Cohen et al. , 2005). , 2001). Thus, blocking CD1 upregulation during the process of monocyte differentiation into DC may occur in some instances, and downregulating CD1a, b, and c molecules already expressed on DC appears to be more difficult and the effects may be partial and donor dependent.
2007). , 2004a). The same study also identified another endosomal lipid modifying protein, GM2 activator, as capable of transferring a-GalCer onto CD1d molecules. Thus, for CD1 molecules localized in lysosomes, successful antigen loading likely depends on the combination of optimal pH and assistance of saposins. 3. GROUP I CD1: CD1a, b, AND c MOLECULES AND T CELLS The human CD1 genes are organized into Group 1 (CD1a, b, c), Group 2 (CD1d), and Group 3 (CD1e) based on sequence similarity and organization in the locus.
Tuberculosis, M. bovis BCG, L. , 2002). In most instances, live infection is necessary to prevent CD1a, b, and c expression. , 2006). Besides blocking induction of CD1 expression, some pathogens also appear to selectively downregulate CD1 molecules that are already expressed on DC. , 2004). , 2006). , 1998a,b), live infection with M. tuberculosis downregulated surface CD1 expression in DC. , 1997) and expression was actually upregulated strongly in another 34 Nadia R. Cohen et al. , 2005). , 2001).
Advances in Immunology, Vol. 102 by Frederick W. Alt