By J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle
Each one quantity of Advances in Pharmacology presents a wealthy selection of stories on well timed subject matters. Emphasis is put on the molecular bases of drug motion, either utilized and experimental.
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Extra resources for Advances in Pharmacology, Vol. 39
Hamilton, S. R. ( 1993). The molecular genetics of colorectal neoplasia. Gastroenterology 105, 3-7. Hixson, L. , Earnest, D. , Fennerty, M. , and Sampliner, R. E. NSAID effect on sporadic colon polyps. Am. J . Gastroenterol. 88, 1652-1656. Hixson, L. , Alberts, D. , Gross, P. , Paranka, N. , and Pamukcu, R. Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells. Cancer Epidemiol. Biomarkers Prev. 3, 433-438. , and Neilson, K. Human cyclooxygenase-2 cDNA.
1995). Steroid hormones other than progesterone or glucocorticoids are probably not biologically important for the regulation of MMTV transcription during lactation, however. A number of additional regulatory elements located near the start of transcription have been found to contribute to the regulation of MMTV transcription in various cultured cell lines. , 1987). , 1992) (Fig. 2B). Viral transcripts can also be found in lymphoid tissues (Henrard and Ross, 1988); the sequences controlling MMTV expression in B and T cells have not yet been defined.
When these mice were nursed on C3H/HeN mothers that produced milk-borne MMTV( C3H), they were resistant to infection relative to their nontransgenic littermates that retained cognate T cells (Fig. 5 ) . , 1993b). Unlike MMTV(C3H), this virus interacts with VP6' T cells because of sequence differences in its Sag hypervariable region (Fig. 4B). The Sag protein encoded by Mtv-7, which is highly homologous to that of the SW virus, also causes the deletion of VP6+ T cells. Held and colleagues (1993b) showed that inbred mouse strains containing Mtv-7 were resistant to the SW but not the MMTV(C3H) virus.
Advances in Pharmacology, Vol. 39 by J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle