Read e-book online Animal Models of Speech and Language Disorders PDF

By David B. Rosenfield M.D. (auth.), Santosh A. Helekar (eds.)

ISBN-10: 1461483999

ISBN-13: 9781461483991

ISBN-10: 1461484006

ISBN-13: 9781461484004

Basic study over the past decade or has exposed similarities among speech, particularly its sensori-motor features, and vocal conversation in numerous non-human species. the main entire stories to date were carried out in songbirds. Songbirds provide us a version process to check the interactions among developmental or genetic predispositions and tutor-dependent impacts, at the studying of vocal communique. Songbird learn has elucidated mobile and molecular mechanisms underlying studying and construction of vocal styles, conception of vocal sounds, vocal motor regulate and vocal neuromotor plasticity. extra lately, the whole genome of the songbird zebra finch has been sequenced. those discoveries, besides the identity of a number of genes implicated in familial human speech and language issues, have made it attainable to appear for analogues of speech and language disorder in zebra finches, at the least on the perceptual and sensori-motor degrees. ways particularly have led us towards the advance of animal versions of human speech stipulations, specifically developmental stuttering and a familial verbal dyspraxia linked to a mutation within the gene for the transcription issue FoxP2. paintings on different animals that exhibit developmental sensori-motor studying of vocal sounds used for conversation have additionally proven major growth, resulting in the opportunity of improvement of types of speech and language disorder in them. between mammals, the relevant ones comprise dolphins and whales. In non-human primates, whereas vocal studying consistent with se isn't renowned, investigations on their communicative skills have thrown a few mild at the rudiments of language. those issues make the booklet of a publication interested in animal versions of speech and language problems, detailing the final investigative procedure of neurobehavioral stories in animals able to vocal verbal exchange and realized vocalizations, a much-needed and helpful undertaking. it's going to function a unifying assessment of analysis during this new multidisciplinary frontier, spanning the molecular to the behavioral, for clinicians and researchers, in addition to a instructing source for complex speech pathology and neuroscience scholars. This publication can be the 1st of its kind.

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Mol Cell Biol 24(2):809–822 49. Ferland RJ, Cherry TJ, Preware PO, Morrisey EE, Walsh CA (2003) Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain. J Comp Neurol 460(2):266–279 50. Lai CSL, Gerrelli D, Monaco AP, Fisher SE, Copp AJ (2003) FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain 126(Pt 11):2455–2462 51. Takahashi K, Liu F-C, Hirokawa K, Takahashi H (2008) Expression of Foxp4 in the developing and adult rat forebrain.

Alcock KJ, Wade D, Anslow P, Passingham RE (2000) Pitch and timing abilities in adult lefthemisphere-dysphasic and right-hemisphere-damaged subjects. Brain Lang 75(1):47–65 34. Tallal P, Sainburg RL, Jernigan T (1991) The neuropathology of developmental dysphasia: behavioral, morphological, and physiological evidence for a pervasive temporal processing disorder. Read Writ 3(3–4):363–377 35. Belton E, Salmond CH, Watkins KE, Vargha-Khadem F, Gadian DG (2003) Bilateral brain abnormalities associated with dominantly inherited verbal and orofacial dyspraxia.

Dysmorphic features were not observed in the family, and they did not meet the criteria for ASD, although the mother and son were classified with pervasive developmental disorder-not otherwise specified (PDD-NOS). The proband displayed severe DVD, expressive language impairment and motor planning defects, while his mother presented with a more moderate phenotype. Thus, in this pedigree, the maternally inherited deletion (in the proband) produced a very severe phenotype of DVD, in contrast to the suggestion of parentof-origin effects [65].

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Animal Models of Speech and Language Disorders by David B. Rosenfield M.D. (auth.), Santosh A. Helekar (eds.)


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