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Extra info for Annual Review of Immunology Volume 15 1997

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The IL-2/IL-2 receptor system: a target for rational immune intervention. Immunol. Today 14:264–70 92. Hatta Y, Hirama T, Miller CW, Yamada Y, Tomonaga M, Koeffler HP. 1995. Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. Blood 85:2699–704 93. Sakashita A, Hattori T, Miller CW, Suzushima H, Asou N, Takatsuki K, Koeffler HP. 1992. Mutations of the p53 gene in adult T-cell leukemia. Blood 79: 477–80 94. Miyoshi I, Kubonishi I, Yoshimoto S, Shiraishi Y. 1981.

Annu. Rev. Immunol. 1997. 15:39–61 Copyright c 1997 by Annual Reviews Inc. uk KEY WORDS: H-Y, transplantation, Ir genes, sex determination, T cell epitopes ABSTRACT H-Y was originally discovered as a transplantation antigen. In vivo primary skin graft responses to H-Y are controlled by immune response (Ir) genes mapping to the MHC. In vitro T cell responses to H-Y are controlled by MHC class I and II Ir genes, which-respectively, restrict CD8 and CD4 T cells: These can be isolated as T cell clones in vitro.

14:31 Annual Reviews ar026-02 AR26-02 UCHIYAMA their constitutive cytokine production. J. Clin. Invest. 95:852–58 Yamaguchi K, Mochizuki M, Watanabe T, Yoshimura K, Shirao M, Araki S, Miyata N, Mori S, Kiyokawa T, Takatsuki K. 1994. Human T lymphotropic virus type 1 uveitis after Graves’ disease. Br. J. Ophthalmol. 78:163–66 Kitajima I, Yamamoto K, Sato K, Nakajima Y, Nakajima T, Maruyama I, Osame M, Nishioka K. 1991. Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy.

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