Annual Review of Immunology Volume 5 1987 by The Annual Reviews PDF

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Extra resources for Annual Review of Immunology Volume 5 1987

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B. , Frampton, J. 1982. Completion of the amino acid sequences of the A and B chains of subcomponent Clq of the first component of human complement. Biochem. J. 203 : 559-69 15. Reid, K. B. M. 1979. Complete amino acid sequences of the three collagenlike regions present in subcomponent Clq of the first component of human complement. Biochem. J. 179:367-71 16. Reid, K. B. , Lowe, D. , Porter, R. R. 1972. Isolation and characterization of Clq, a subcomponent of the first component of complement, from humanand rabbit sera.

Small molecule inhibitors still diffuse through the cage to reach their binding sites on Clr, to prevent activation (3). Ziccardi (60) found C 1-inhibitor more effective in preventing activation by immunecomplexes at 20°C than at 37°C. Assuming that the binding sites are located on the outsides of the Clq heads (that is, facing away from the axis) as proposed by Kilchherr et al (22), we suggest the C1, with inhibitor still attached, initially binds with its axis parallel to the surface of the immunecomplex.

201 : 61-70 54. Bing, D. H. 1969. Nature of the active site of a subunit of the first component of humancomplement. Biochemistry 8 : 4503-10 55. Ziccardi, R. , Cooper, N. R. 1979. Active disassembly of the first component of complement, C]-, by C]--inactivator. J. 123 : 788-92 56. Sim, R. , Arlaud, G. , Colomb,M. G. 1980. Kinetics of reaction of human CI-inhibitor with the human complement system proteases C]~ and CI~. Biochim. Biophys. Acta 612:433-49 57. , Wiman,B. 1983. Kinetics of the reaction between human C1esterase inhibitor and Cl-r or C’fs.

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