Download e-book for iPad: Antibody Production in Man: In Vitro Synthesis and Clinical by Anthony S. Fauci, R. Ballieux

By Anthony S. Fauci, R. Ballieux

ISBN-10: 0323151523

ISBN-13: 9780323151528

398 pages

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Additional info for Antibody Production in Man: In Vitro Synthesis and Clinical Implications

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Blood lymphocytes tested under similar conditions did not respond readily. This finding indicated that distinct populations of B cells reside in different lymphoid organs in humans, and that the responsiveness registered in blood lymphocytes might not be representative of the response of all human B cells. A careful and extensive study by Kunori et al. (1978) has revealed different response patterns for human blood and splenic lymphocytes by LPS, and above all, has shown that · with the correct experimental protocol, blood lymphocytes respond well to LPS.

Fauci and Barton F. Haynes 26 I M | EXPECTED RESPONSE OBSERVED RESPONSE CO-CULTURES OF: RESPONDERS CO-CULTURES OF: RESPONDERS RESPONDERS NON-RESPONDERS + + FIGURE 5. Effect of co-culture of non-responder with responder lymphocytes. 01). There is no suppression when responder and allogeneic responder lymphocytes are co-cultured. Data represent the mean (±SEM) of 8 separate experiments. Subsequent experiments were performed to determine which subpopulation(s) of mononuclear cells were responsible for this suppressor phenemenon.

Proc. II, 119, Rev. 37, 1213 1123 (1959). 36, 2166 (1977). 28a. , Ralison, A. , Nurse, G. , Lane, A. , and Hopkinson, D. , J. Pediatrics 89, 732 (1976). 29. Hayward, A. , Lancet 30. Pearl, E. , Vogler, L. , Okos, A. , Crist, W. , Lawton, A. R. , and Cooper, M. , J. Immunol. 120, 1169 (1978). 31. i , 1014, 1978. Bernier, G. , Gunderman, J. R. , and Ruymann, F. , Blood 40, 795. 32. Zegers, B. J. , Mul, N. A. , Stoop, J. , Vossen, J. , and Ballieux, R. , N. Engl. J. Med. 294, 1026 (1976). 33. , and Oberdorfer, A.

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Antibody Production in Man: In Vitro Synthesis and Clinical Implications by Anthony S. Fauci, R. Ballieux


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