By Bruno Gander, Hans P Merkle, Giampietro Corradin
This article offers an updated assessment of contemporary advancements during this box, reports new tendencies in vaccine improvement courses, and emphasizes the necessities and value of assorted vaccine supply platforms.
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Extra info for Antigen Delivery Systems: Immunological and Technological Issues (Drug Targeting and Delivery)
1994). Determinants recognized by virus-, tumor-specific and alloreactive T cells are borne by proteins synthesized by the APC themselves. It cannot be a priori excluded that loading of determinants from membrane-bound and secreted proteins could take place in the ER. DEMOTZ Figure 2 Schematic view of the assembly of complexes between peptides generated in the endosomal/lysosomal compartment and class II MHC heterodimers. , 1994). This situation is expected to be unfavorable for capture of peptides in the ER.
As such, the 20S proteasome is only active on small polypeptides. To efficiently degrade native proteins, the 20S proteasome relies on an additional structure, the 19S cap, composed of 16 proteins which assemble in the presence of ATP at both ends of the barrel-like structure of the proteasome, giving rise to a fully active 1500–2500 kDa multimer, the 26S proteasome. , 1995). , 1995). Ubiquitination involves at least three enzymes, E1 to E3. DEMOTZ which each member displays a specific cellular localization and substrate preference.
Klibanov, A. and Langer, R. (1995) Stabilization of tetanus and diptheria toxoids against moisture-induced aggregation. Proc. Natl. Acad. Sci. USA, 92, 11234–11238. , and Langer, R. (1996) Strategies for stabilizing tetanus toxoid towards the development of a single-dose tetanus vaccine. Dev. Biol. , 87, 293–306. P. (1991) Controlled delivery of diphtheria toxoid using biodegradable poly (D, L lactide) microcapsules. Pharm. , 8, 958–961. State of the world’s vaccines and immunization. 04. P. and Gander, B.
Antigen Delivery Systems: Immunological and Technological Issues (Drug Targeting and Delivery) by Bruno Gander, Hans P Merkle, Giampietro Corradin