By William Shafer
Microbes are in our midst quickly after start. fortunately, the variety of innocuous (and usually important) microbes some distance outnumber those who may do us damage. Our skill to ward-off pathogens in our surroundings, together with those who can colonize our external and/or inside surfaces, relies on the integrative motion of the innate and adaptive immunity platforms. This quantity of CTMI, entitled Antimicrobial Peptides and Human disorder, is devoted to the position of antimicrobial peptides (AMPs) within the innate host security approach of homo sapiens.
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Additional info for Antimicrobial Peptides and Human Disease (Current Topics in Microbiology and Immunology)
2002). g. ≤10 µg/ml ) of neutrophil defensins (HNP1–3) induce proliferation of a lung epithelial cell line in vitro (Aarbiou et al. 2002). Consistent with these observations, a combination of HNP1–3 caused a dose- and time-dependent increase in cell migration and wound closure of an airway epithelial cell line, possibly due to an ability to induce the expression of genes involved in proliferation (Aarbiou et al. 2004). The mitogenic activity of the HNPS and cathelicidins does not appear to be shared by the β-defensins.
Epithelial Cells . . . . . . . . . . . . . . . . . . . . . 2 Host Defence Peptides in the Adaptive Immune Response . . . . . . 46 Adjuvant Activity . . . . . . . . . . . . . . . . . . . . 46 Mechanisms . . . . . . . . . . . . . . . . . . . . . . 50 4 Conclusion . . . . . . . . . . . . . . . . . . . . . . 53 References . . . . . . . . . . . . . . . .
2003). HNPs are potent mitogens for epithelial cells, squamous cell carcinoma cell lines and ﬁbroblasts in vitro at low concentrations (Murphy et al. 1993; M. Nishimura et al. 2004). Interestingly, in one of the earliest studies of these effects it was demonstrated that the HNPs acted synergistically with insulin to induce proliferation (Murphy et al. 1993). In general it has been hypothesised that the mitogenic properties of the neutrophil defensins on non-myeloid cells is an important component of the healing process.
Antimicrobial Peptides and Human Disease (Current Topics in Microbiology and Immunology) by William Shafer