A. Szenberg (auth.), Albert A. Benedict (eds.)'s Avian Immunology PDF

By A. Szenberg (auth.), Albert A. Benedict (eds.)

ISBN-10: 1461341698

ISBN-13: 9781461341697

ISBN-10: 146134171X

ISBN-13: 9781461341710

The ontogeny of lymphoid cells turns out the main applicable position to begin. The early occasions in T and B cellphone ontogeny are nonetheless complicated. There appears to be like no contract at the facts and at the semantics of the query of progenitor vs. stem cells. however, we're commencing to comprehend extra approximately progenitor cells that are devoted to specific telephone traces, and approximately stem cells within the feel of getting virtually limitless strength of giving upward push to undifferentiated progeny. a tremendous destiny improvement may be to figure out the character of the ingredients that allure stem cells and that are produced via really expert thymus epithelium, and maybe via the bursa. the best way stem cells realize those signs is a vital query to respond to. now not predictable from mammalian versions has been the remark that there's a loss of cells known as into the bursa even earlier than the sign for access of stem cells has been close off. a probable version prompt that when a undeniable element in improvement there have been not any cells able to migrating into the bursa and changing into B cells. a desirable threat is the advice phone comes into the bursa, isn't really dedicated, then can nonetheless wander into the thymus. This mobile doesn't seem to have B mobilephone characteris­ tics; that's, immunoglobulin isn't really expressed on its surface.

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Extra info for Avian Immunology

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Arrow along the abscissa indicates the day of hatching. Vertical bars represent standard error of the mean. Section of lymphoid colony, derived from a 2-day-old chicken spleen, on the CAM of a chicken embryo. The majority of cells in this colony have the characteristics of lymphocytes (x 480). Hematoxylin - Eosin stain. 26 G. KELLER ET AL. DISCUSSION The development of an avian hemopoietic colony assay has enabled us to study the ontogeny of hemopoietic colony-forming units within the spleen of the chicken embryo.

D'Embryologie du CNRS et du College de France Nogent s/Marne 94130 - FRANCE 1:Lab. d'Embryologie de la Faculte des Sciences de Nantes - FRANCE The avian embryo provides a convenient model to investigate the ontogeny of the primary lymphoid organs since birds are the only vertebrates in which the sites of differentiation of both T and B lymphocytes are known. On the other hand, the accessibility of the avian embryo during the whole developmental period makes it an elective experimental material for studying problems related to morphogenesis and organogenesis.

O Sulfate Anti-CIgY Donor Cells 150 - ~ ~ . o A. A. o Host Cells . 5 10 Weeks Afler Transfer of 14 Day Embryonic Bone Morrow Cells 10 14 Day Old Embryos Figure 2. Top: Distribution of cells of donor karyotype in bone marrow, thymus, spleen and bursa of recipients at different intervals after cell transfer. Mid-Bottom: Net number of dividing Con A responsive T cells of donor (host) origin, as well as the number of dividing Anti-Crg and Dextran Sulfate responsive B cells of donor (host) origin per 10 4 cells in spleen and thymus cell cultures of recipients.

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Avian Immunology by A. Szenberg (auth.), Albert A. Benedict (eds.)


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