By Céline Bouquet, Fatiha Nothias (auth.), Dominique Bagnard Ph.D. (eds.)
The complexarchitectureofneuronal networks togetherwith the extreme linked features make the anxious process a desirable organic constitution. The huge paintings played to discover this mobile equipment is these days successfulbecause the mysteryofnervous procedure developmentisbeing unravelled. As defined of their impressive evaluation released 10 years in the past in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular period of axon guidance-summarized the meeting of fearful procedure connections as a sophisticated video game of appeal and repulsion of neuronal progress cones. The mobile ballet making sure the formation of billions of synapses, which eventually supplies upward push to the top cognitive features, is basically orchestrated by means of a step by step mechanism of development pushed through a number of molecular cues. whereas our basic proposal of axon assistance is still exact, a profound evolution ofour wisdom ofthe molecular identityofthe advice cues including their interactions and signalling pathways happened during the last ten years. This publication proposes an exhaustive and up-to-date view ofthe present wisdom ofthe molecular and mobile mechanisms making sure axon progress and tips. An introductory chapterby C. Bouquetand F.Nothias will remind the readers ofall the beneficial properties ofa progress cone and the mechanisms controlling its development. From there, one enters a superb trip with a development cone, a Tom Thumb tale packed with molecular encounters and intricate interactions resulting in one ofthe most fabulous developmental achievements: the frightened process wiring.
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Extra info for Axon Growth and Guidance
Neumann S, Bradke F, Tessier-Lavigne M et al. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron 2002: 34:885-93. 117. Cai D, Qiu J, Cao Z et al. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci 2001: 21:4731-9. 118. Fournier AE, Takizawa BT, Strittmatter SM. Rho kinase inhibirion enhances axonal regeneration in the injured CNS. J Neurosci 2003; 23:1416-23. 119. Niederost B, Oertle T, Fritsche J et al.
J Neurosci 2005; 25:10119-10130. 42. Deiner MS, Kennedy TE, Fazeli A et aI. Netrin-I and DCC mediate axon guidance locally at the optic disc: Loss of function leads to optic nerve hypoplasia. Neuron 1997; 19:575-589. 43. Lin L, Rao Y, Isacson O. Netrin-l and slit-Z regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Mol Cell Neurosci 2005; 28:547-555. 44. Braisted JE, Catalano SM, Stimac R et aI. Netrin-I promotes thalamic axon growth and is required for proper development of the thalamocortical projection.
J Neurosci 2004; 24:10826-10834. 60. Kolodziej PA, Timpe LC, Mitchell KJ et al. Frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 1996; 87:197-204. 61. Hall A. Rho GTPases and the actin cytoskeleton. Science 1998; 279:509-514. 62. Luo L. Rho GTPases in neuronal morphogenesis. Nat Rev Neurosci 2000; 1:173-180. 63. Dickson BJ. Rho GTPases in growth cone guidance. Curr Opin Neurobiol 2001; 11:103-110. 64. Shekarabi M, Moore SW, Tritsch NX et al.
Axon Growth and Guidance by Céline Bouquet, Fatiha Nothias (auth.), Dominique Bagnard Ph.D. (eds.)