By Anna Tampieri, Simone Sprio
ISBN-10: 1631661701
ISBN-13: 9781631661709
ISBN-10: 9814669156
ISBN-13: 9789814669153
This e-book offers a large and interdisciplinary assessment of the present cutting-edge within the improvement of biomimetic fabrics for tissue regeneration at the foundation of correct and high-impact medical wishes. It in particular emphasizes the regeneration of bone, cartilage, and osteochondral tissues in addition to delicate tissues comparable to nerves, center, and endocrine organs. It brings jointly contributions from fabrics scientists, biologists, and surgeons with globally well-known event within the box of regenerative medicine.
The target of the ebook is to focus on the relevance of biomimetics as an optional procedure for the improvement of latest scaffolds that could direct regenerative cascade by way of chemico-physical and topological nano-cues provided to cells and biologic tissues. rather, the publication refers to rising ideas in synthesis strategies and scaffolds encouraged by way of nature in addition to to novel ways for clever functionalization comparable to using magnetic signaling.
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Extra resources for Bio-inspired regenerative medicine : materials, processes, and clinical applications
Sample text
J. Kao, Monocyte activation in response to polyethylene glycol hydrogels grafted with RGD and PHSRN separated by interpositional spacers of various lengths. Journal of Biomedical Materials Research Part A, 2007. 83(3), pp. 617–625. 40. , Glycine-spacers influence functional motifs exposure and self-assembling propensity of functionalized substrates tailored for neural stem cell cultures. Frontiers in Neuroengineering, 2010. 2010. 41. , Collective review: Bioactive implants coated with poly(D,L-lactide) and growth factors IGF-I, TGF-b1, or BMP-2 for stimulation of fracture healing.
Furthermore, the linkage of growth factors to the ECM protects them from enzymatic cleavage and prevents fast diffusion within the tissue [49]. In addition, growth factor activity may be enhanced by localization within the ECM, allowing interaction with its specific ligands [49]. Conversely, some growth factors (examples) may be inactivated by their adhesion to the ECM and while they can act on their target when released by matrix proteolysis [51], requiring the action of ECM-degrading enzymes expressed by the cells regulated by growth factors and ECM adhesion domains.
S. (1997). Use of electromagnetic fields in a spinal fusion: A rabbit model, Spine, 22, pp. 2351−2356. 36. Yan, Q. , and Ikada, Y. (1998). Effects of static magnetic field on bone formation of rat femurs, Med. Eng. , 20, pp. 397−402. 37. , Sachinis, N. , and Chalidis, B. E. (2012). Pulsed electromagnetic fields for the treatment of tibial delayed unions and nonunions. A prospective clinical study and review of the literature, J. Orthop. Sur. , 7, p. 24. 38. , and Maccauro, G. (2011). Stimulation of bone formation and fracture healing with pulsed electromagnetic fields: Biologic responses and clinical implications, Int.
Bio-inspired regenerative medicine : materials, processes, and clinical applications by Anna Tampieri, Simone Sprio
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