Blood Substitutes: New Challenges by Robert M. Winslow M.D. (auth.), Robert M. Winslow M.D., Kim PDF

By Robert M. Winslow M.D. (auth.), Robert M. Winslow M.D., Kim D. Vandegriff Ph.D., Marcos Intaglietta Ph.D. (eds.)

ISBN-10: 1461241146

ISBN-13: 9781461241140

ISBN-10: 146128659X

ISBN-13: 9781461286592

This publication isn't a "proceedings" quantity. really the chapters are essays by means of specialists within the box of blood substitutes, invited via the editors to con­ tribute to the 1996 "Current concerns in Blood Substitutes study and improvement" direction given in San Diego, March 18-21. The individuals have been chosen as a result of their services in parts deemed through the editors to be serious to the development of the sector. The path, as in prior years, is seriously prompted by way of suggestions from par­ ticipants, and by means of examine during this and comparable fields. as well as the didactic lectures (for which those chapters are the foundation), the direction additionally deals the chance for presentation of analysis studies, growth stories from some of the businesses presently commercializing items, and around desk discussions of chosen topics. hence, we're thankful to previous individuals for his or her invaluable reviews. construction of a e-book, particularly on a quick timeline, isn't really a simple feat.

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Extra resources for Blood Substitutes: New Challenges

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Traumatic shock represents a subset of hypovolemic shock, in which a critical reduction of blood volume is superimposed by the effects of tissue injury, eliciting the activation of inflammatory and coagulation systems. Trauma in conjunction with severe hypovolemia and shock remains the leading cause of morbidity and mortality of patients under 45 years of age (Baker 1986, McCabe 1990). 2 Redirection of organ blood flow Hypovolemia affects myocardial performance predominantly through the decrease of cardiac output via the Frank-Starling mechanism.

L. Stetler. A human recombinant haemoglobin designed for use as a blood substitute. Nature 356: 258-260, 1992. G. J. F. A. Rapp. Perioperative myocardial ischemia in patients undergoing noncardiac surgery-oIl: incidence and severity during the 1st week after surgery. ) Research Group. J. Am. Coll. Cardiol. 17: 851-857, 1991. J. Sacks, and D. Goldfinger. Safety of autologous blood donation prior to elective surgery for a variety of potentially "high-risk" patients. Transfusion 23: 229-232, 1983.

Infarction of about 40 percent of the ventricle myocardium generally results in cardiogenic shock. Through the sympatho-adrenergic reaction, perfusion pressure in the coronary circulation rises. However, myocardial oxygen requirements are concomitantly elevated as a result of tachycardia, an increase of myocardial contractility, and left ventricular afterload. Since oxygen extraction of the myocardium already under normal conditions is highest among all organs, the increased oxygen need can only be satisfied through an enhanced coronary blood flow.

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Blood Substitutes: New Challenges by Robert M. Winslow M.D. (auth.), Robert M. Winslow M.D., Kim D. Vandegriff Ph.D., Marcos Intaglietta Ph.D. (eds.)


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