By Dass S. Vinay, Byoung S. Kwon (auth.), Lieping Chen (eds.)
This entire quantity, written by way of specialists within the box, covers approximately all facets of ongoing examine on the topic of the CD137 pathway. contemporary examine has proven that the manipulation of CD137 pathway molecules is particularly promising within the remedy of melanoma, viral an infection, transplantation rejection and autoimmune ailments in experimental animal types. the quantity contains learn relating to the id and knowing of useful effects of CD137 receptor and ligand molecules which represents a tremendous attempt within the box of immunology. CD137 Pathway: Immunology and ailments is a perfect publication for immunologists, microbiologists, melanoma researchers, molecular biologists, biochemists, and pharmaceutical and biotechnology corporation scientists.
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Extra resources for CD137 Pathway: Immunology and Diseases
1. 1. 2). The signal through CD137 ligand activates monocytes and the CD137 ligand signal alone is sufficient for activation. When CD137 ligand is crosslinked by recombinant CD137 protein or an anti-CD137 ligand antibody, it induces adherence of monocytes within a few hours. The adherent monocytes change their shape over the course of a week and adopt the three basic macrophage morphologies, which are round, elongated, and branched cells (Langstein and Schwarz, 1999). , 1998). 1. Activities of CD137 Ligand Signaling by Cell Type.
1997). 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. , 186, 46–55. P. (2000). Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses. Transplantation, 70, 175–183. , and Hunter, T. (1994). p27, a novel inhibitor of G1 cyclin/Cdk protein kinase activity, is related to p21. Cell, 78, 67–74. , and Zhang, H. (1999). p27 (Kip1) ubiquitination and degradation is regulated by the SCF (Skp2) complex through phosphorylated Thr187 in p27.
Role of the CD137 receptor/ligand system in (A) the initiation and maintenance, and (B) the downregulation of T cell responses. (A) At the beginning of an immune response T cells receive activating signals from dendritic cells (DC) through CD137 and other costimulatory molecules. The inhibitory signals through CD137 ligand are blocked by activating signals. (B) Once the cause of the immune response has been eliminated, the dendritic cell will no longer provide activating signals and inhibit CD137 ligand-mediated apoptosis in T cells.
CD137 Pathway: Immunology and Diseases by Dass S. Vinay, Byoung S. Kwon (auth.), Lieping Chen (eds.)