By Anthony R. Mire-Sluis and Robin Thorpe (Eds.)
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The production of IL-3 is, in contrast to other hemopoietic growth factors, restricted to a few cell types, such as activated T lymphocytes and mast cells, underlying its role in inducible but not constitutive hemopoiesis. Beside its effects on immature myeloid progenitor cells, IL-3 acts on mature end-stage myeloid cells, such as basophils and eosinophils, by priming histamine release and generation of leukotrienes by IgE-dependent and -independent mechanisms, suggesting an essential role in allergic responses.
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A. (1996). Rational interleukin 2 therapy for HIV positive individuals: Daily low doses enhance immune function without toxicity. Proc. Natl Acad. Sci. USA 93, 10405-10410. , Kingston, R. J. (1987). Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors. Nature 329, 160-162. , Efrat, S. and Marsh, S. (1987). Regulation of human interleukin 2 gene expression. In "Lymphokines, Vol. 13, Molecular Cloning and Analysis of Lymphokines", (eds. R. V. Goeddel), pp. 59-72.
Cytokines by Anthony R. Mire-Sluis and Robin Thorpe (Eds.)