By Peter J. Watkins, Stephanie A. Amiel, Simon L. Howell, Eileen Turner
Hugely recommended within the 2004 BMA scientific booklet pageant (Endocrinology)Judges’ summary:“Beautifully and obviously written to entice all degrees of health practitioner wisdom. A wealth of sensible event is freely donated to the reader in a pleasant and available method. each one part is well chanced on and any member of the staff may take care of a sufferer with that exact challenge to a excessive common with this ebook of their hand. i'd unhesitatingly suggest to all diabetes medical professionals – either senior and junior, and each diabetes unit must have a duplicate. This re-creation is superb and may be thought of for an award.”Diabetes and its administration, 6th version, keeps to supply a pragmatic medical consultant to the administration of sufferers with diabetes. the writer crew has been accelerated and now additionally incorporates a Nurse Practitioner specialising in diabetes to supply the nursing point of view. it's a concise handbook that distils the basic contemporary advancements into sensible recommendation.
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Extra info for Diabetes and Its Management 6th Edition
These changes are the result of severe insulin deficiency and are summarized in Fig. 1. Insulin deficiency depresses glucose transport and glycogen synthesis in tissues such as muscle. Glucose utilization is slowed as a result of the defective activity of a number of enzymes in the glycolysis pathway. At the same time, there is a depression of protein synthesis and a corresponding increase in protein breakdown. Overproduction of glucose from this source complements glucose underutilization to produce hyperglycaemia.
Tiredness is not a feature of adequately treated diabetes although many patients, usually those with a mild depressive tendency, continue over many years to believe so. Pruritus vulvae is a presenting symptom in about two-fifths of Type 2 diabeticwomen and is associated by women with Type 1 disease as indicative of lost glycaemic control; this, and balanitis in men, is a result of monilial infection which occurs more readily in the presence of glycosuria. Doctors often fail to recognize the potential relevance of this symptom and patients are frequentlytreated for symptomatic relief without any thought of the possibility of diabetes.
HLA, human leucocyte antigen; TNF, tumour necrosisfactor. A. & I I I n t II 1I I I DP DQ Class 111 Class I region I n nnn n n n u u u u u U II pa DR HLA region Role of the HLA system The major histocompatibility complex antigens (MHCs) are adjuncts to several types of immunologicalactivity. They are glycoproteins present on the surface of cells, and they are coded by genes on the short arm of chromosome 6 (Fig. 2). In humans, the major histocompatibility antigens are termed HLA antigens (or human leucocyteassociated antigens), because they were originally found on human leucocytes.
Diabetes and Its Management 6th Edition by Peter J. Watkins, Stephanie A. Amiel, Simon L. Howell, Eileen Turner